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Pirfenidone for IPF: pro/con debate; the 'con' viewpoint.
Improving outcomes for patients with idiopathic pulmonary fibrosis (IPF) remains a major unmet healthcare need— in this, we entirely agree with the ‘pro’ debate article by Gisli Jenkins. In this regard, the efforts of drug companies in developing novel drugs and collaboration with expert clinical investigators in the field of IPF in wanting to demonstrate the therapeutic efficacy for patients w...
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Ríos et al. (2004) report in this issue that the Golgi protein GMAP-210 is sufficient to confer pericentrosomal positioning and recruits gamma-tubulin and associated microtubule-nucleating ring complex proteins to Golgi membranes. The results raise the possibility that short microtubules emanate from the Golgi to mediate its organization and positioning.
متن کاملThe Golgi apparatus
At some point in their lives all cells need to grow and divide. In eukaryotic cells these processes require the delivery of new proteins and lipids from their site of synthesis in the endoplasmic reticulum (ER) to the cell surface. The Golgi apparatus, first visualised under the light microscope in 1898 by Camillo Golgi using a staining method he had developed to study neurons, lies on the rout...
متن کاملThe Mitotic Apparatus
Mitotic apparatuses (MA) isolated from metaphase sea urchin eggs in 12% hexylene glycol at pH 6.4 can be dissolved rapidly in 0.6 M KCl, and more than one-half of the total protein of the MA is soluble under these conditions. In the phase-contrast microscope, the fibrous structure of the MA can be seen to disintegrate in KCl solution, leaving only granular material which, in the electron micros...
متن کاملThe DAMA/LIBRA apparatus
The ≃ 250 kg highly radiopure NaI(Tl) DAMA/LIBRA apparatus, running at the Gran Sasso National Laboratory (LNGS) of the I.N.F.N., is described.
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ژورنال
عنوان ژورنال: Anaesthesia and Intensive Care
سال: 2005
ISSN: 0310-057X,1448-0271
DOI: 10.1177/0310057x0503301s03